XWH - 08 - 1 - 0392 TITLE : Activating Cell Death Ligand Signaling Through Proteasome
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منابع مشابه
15-Deoxy-Δ12,14-Prostaglandin J2 Protects PC12 cells from LPS-Induced Cell Death Through Nrf2 pathway in PPAR-γ Dependent Manner
Introduction: The inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), has been demonstrated to have anti-inflam...
متن کاملW 81 XWH - 08 - 1 - 0209 TITLE : A Mechanistic Study of Proapoptotic Daxx - Par 4 Axis in Prostate Cancer PRINCIPAL INVESTIGATOR :
presentation Puto, L.A., Kitada, S., Krajewska, M., Glinsky, G., Hunter, T., and Reed, J.C. Transcriptional repressor Daxx regulates Dapk1 expression, autophagy, apoptosis, and tumorigenicity of prostate cancer cells. American Association for Cancer Research, Special Conference: Cell Death Mechanisms and Cancer Therapy; February 1-4, 2010; San Diego, California; Abstract # A7.
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Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.
Wolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent diabetes mellitus, caused by nonautoimmune loss of beta cells, and neurological dysfunctions. We have previously shown that mutations in the Wolfram syndrome 1 (WFS1) gene cause Wolfram syndrome and that WFS1 has a protective function against ER stress. However, it remained to be determined how WFS1 mitigates...
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